Porteur
Cristiana Pereira
Session
2018
Co-porteur(s)
João Paulo Teixeira
Titre
GenoRESPIRA – Genetic damage and immune activation in patients with COPD in Estarreja
Résumé
Oxidative stress has already been associated with numerous conditions, including chronic obstructive pulmonary disease (COPD). The exact pathways and factors of oxidative stress involved in the disease process are still loosely known, yet are the key to therapeutic and prevention applications. With the GenoRESPIRA project we aim to characterize a population of COPD patients from Estarreja regarding their oxidative stress levels and DNA damage, and look for possible factors contributing to them. After characterizing the indoor contaminants in this specific community with the previous projects RESPIRA and MicroRESPIRA, this new project gives insights to some biological effects of the contaminants found.
Being Estarreja a highly industrialized and therefore contaminated region, this study will help on having a closer and integrated look over the effects of indoor contamination in oxidative stress levels in a diseased population.
Type
Projet OHMs
OHM(s) concerné(s)
  • Estarreja
Disciplines
Éco-épidémiologie, Génétique, Médecine, Santé publique
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Porteur

Cristiana
Pereira
Cristiana Costa Pereira is a Biologist by the University of Porto (UP), and a PhD in Metabolism and Clinical Experimentation by the Faculty of Medicine of the University of Porto. Her PhD thesis is a study over oxidative stress and DNA damage among a large population of inflammatory bowel disease patients. From 1999 until 2004 she worked as a Lab Assistant in the Molecular Biology Laboratory in the Blood Bank Unit from Centro Hospitalar São João, Porto, where she developed techniques to genotype rare blood groups. In 2004 she started working in the National Institute of Health in the Bioemergency Unit, in Lisbon, developing molecular techniques to identify unknown virus and to respond to biological threats. In 2005 she moved to the Oporto Unit of the National Institute of Health as Head of the Clinical Bacteriology Unit, working on the bacteriological and mycological screening of clinical samples as well as in the Quality Control Management of the Lab. Since 2010 she has been working in the Environmental Health Department in the same institute as Head of the Air Microbiology Unit, developing work in the scope of Indoor Air Quality and genotoxicity evaluation studies. She has been a team member of FCT funded projects carried out by the Environmental Health Unit, She has several publications on Indoor Air Quality Evaluation and oxidative stress evaluation. She is a member of the COST Action EPICHEM “Epigenetic Chemical Biology”.

Participants

João
Teixeira
João Paulo Teixeira is a researcher and the Head of Research Unit, Department of Environmental Health in the National Institute of Health (Portugal) since 2005 and coordinator of Environmental and Laboratory Epidemiology (ELE) group from the Epidemiology Research Unit (EPIUnit) of the Institute of Public Health, University of Porto. He has a PhD in Biomedical Sciences and a Master in Public Health from the Medical School of the University of Porto. His research interest include Environmental Toxicology, Epidemiology, Occupational Health, Biomarkers, Genotoxicity, Nanotoxicology and Indoor Air Quality. The main area of scientific activity is concerned with the genetic damage caused by genotoxic and carcinogenic compounds, mainly in the environmental and occupational areas. His work is focused on the molecular mechanisms involved in the cascade of genotoxic/carcinogenic events in relation to exposure to xenobiotics, as well as on the factors of individual susceptibility modulating genotoxic and/or carcinogenic effects. He has published around 100 scientific papers and several book chapters on these topics.
Ana
Sousa
Ana C. A. Sousa graduated in biology by the University of Aveiro in 2001, and completed her PhD in September 2009 at the same institution. Presently she is a postdoc researcher at CICECO, University of Aveiro. Her work focus on environmental contaminants, particularly endocrine disruptors, and their impact in wildlife and human health. She has worked and continues to collaborate with several foreign institutions including the University of Coruña (Spain), the Swiss Federal Institute for Environmental Science and Technology (EAWAG), Switzerland; the National Institute for Environmental Studies (NIES), Japan; the Center for Marine Environmental Studies (CMES), Japan and the Colorado School of Mines, USA.
During her career she has successfully obtained grants from national and international competitive applications (e.g. FCT, Gulbenkian Foundation, and the Japanese government). She is the PI of RESPIRA and microRESPIRA two research projects on the environmental determinants of pulmonary diseases financed by the CNRS/INEE - National Center for Scientific Research/Institute of Ecology and Environment.
Since 2005, she has published 1 book, 2 book chapters and 25 papers in peer reviewed international journals. She has also 13 papers in peer review proceedings of international conferences. She presented 80 communications in conferences. In 2008 she was awarded with the "Best Oral Presentation Award" at the International Conference "Seasink" and in 2016 her work received the Best Poster Award in the National Symposium on Diabesity and Obesity. Her recent work has also received media attention from Portuguese local and national radio stations, TV shows and newspapers.
Ramiro
Pastorinho
Ramiro Pastorinho started his professional life as a high school teacher. After eight years, he started an MSc at the University of Aveiro (UA), which he finished in 2001 while still teaching. He was then invited to pursue a PhD between the UA and the Institute of Aquaculture, University of Stirling, UK. The Degree was concluded in 2008, after a pause of two years working as a technician at UA’s Biology department. Between 2009 and 2014 he was the recipient of a Post-Doctoral grant awarded by FCT, working between the UA, Portugal and Colorado School of Mines, USA. His main research interests include (organo)metals’ dispersal, circulation and speciation in different systems and matrices with a special focus on the influence metals have in human wellbeing and disease. He has been teaching regularly at the Department of Biology-UA since 2011, and is regularly invited to lecture at various Institutions and Universities both in Portugal and USA. Since February 2015 he is an invited assistant professor at the Department of Medicine of the Faculty of Health Sciences, University of Beira Interior, Portugal. Since 2003 he has published 26 papers in SCI indexed, 3 book chapters, and 11 other peer-reviewed publications. He has more than 70 communications in international scientific meetings subjected to peer-reviewing. He also regularly acts as a reviewer for 12 SCI journals. The scientific network of Ramiro Pastorinho is patent in the more than 80 distinct co-authors from highly diverse affiliations with whom he shares his publications.
Raquel
Amaro
Raquel Amaro graduated in Environmental Health by the Coimbra Health School, Polytechnic Institute of Coimbra, in 2013 and carried out one of her final internship course trainees at the Public Health Unit, at Aveiro Health Center, a branch from the regional group ACeS Baixo Vouga. During her degree she completed an international training at Facoltà di Medicina, Università degli Studi Gabriele d'Annunzio – Chieti e Pescara, Italy. Since 2013, she is a master in Toxicology and Ecotoxicology by the University of Aveiro. With her Master thesis she evaluated the fungal communities on house dust samples from dwellings of Chronic Obstructive Pulmonary Disease and Asthmatic patients. Her work is being carried out in collaboration with the National Institute of Health Dr. Ricardo Jorge, Porto. She attended one international and one national conference, where she presented 2 posters and 1 oral communication. She has also published a paper in international conference proceedings.
Filipa
Esteves
Filipa Esteves graduated in Environmental Health by the Porto Health School, Polytechnic Institute of Porto, in 2014. She has also a master degree in Occupational Safety and Hygiene Engineering by the Faculty of Engineering of the University of Porto. Her master thesis evaluated the genotoxicity and oxidative stress among professional dancers. Her work is being carried out in collaboration with the National Institute of Health Dr. Ricardo Jorge, Porto. She attended one international and one national conference, where she actively presented her work on poster presentations. She was the recipient of the Taylor and Francis prize for the best poster presented in the 3rdInternational Conference on Occupational and Environmental Toxicology held in Porto in June 2016.
Dietmar
Fuchs
Dietmar Fuchs studied chemistry at the University of Innsbruck, Austria and graduated in 1980. Since then, he has been working at the Biozentrum of the Medical University of Innsbruck. In 1986, he qualified as a lecturer in medical chemistry with a work on neopterin ("Neopterin - a marker for the status of cell-mediated immunity: Significance for ARC, AIDS and AIDS risk groups"). In 1994 he became an Appointed Professor of the University. From 1994 to 1999 he was Honorary Visiting Fellow and Honorary Senior Research Fellow of the University of Birmingham, U.K.. He is often engaged in scientific organizations among others. From 1997 to 2006 he was co-director of the Ludwig Boltzmann Institute for AIDS Research, Innsbruck, and has been an honorary member of the Austrian Society for Laboratory Medicine and Clinical Chemistry. Since 2011 he works on numerous research projects in the field of immunology, immunobiology, neuroimmunology and laboratory diagnostics, among others. He has more than 500 peer-reviewed publications and an h-index of 76.