Porteur
Regina Regina Maria Brandão De Oliveira Duarte
Session
2018
Co-porteur(s)
Bruno Miguel Rodrigues das Neves, Carla Patinha, Rita Maria Pinho Ferreira, Armando da Costa Duarte
Titre
Air-Inflam: Air particles beyond concentration – linking the characteristics of organic constituents to their immunomodulatory potential in an urban industrialized area (Estarreja, Portugal)
Résumé
Ambient air pollution and atmospheric particulate matter (PM) are implicated in causing or exacerbating respiratory (e.g. asthma, lung cancer) and cardiovascular diseases. In response, the European Union has developed legislation (Directive 2008/50/EC) establishing health based standards and exposure objectives for a series of atmospheric pollutants. Among these pollutants, fine and coarse PM concentrations are considered two important criteria for ambient air quality management. Indeed, the size of PM has been indicated as a key factor controlling their transport and toxicity in lungs. Nonetheless, PM composition has been also suggested to dominate the interaction between particles and epithelial cells and alveolar macrophages, resulting in membrane damage. When exploring the pro-inflammatory potential of specific PM-components, the most consistency findings have been reported for water-soluble transition metals, which account for less than 2% of total PM mass. On the other hand, virtually nothing is known about the immunomodulatory potential of the water-soluble organic matter (WSOM), which can account for up to 40% of total PM mass in urban areas.
Within this context, this project aims at assessing the oxidative and pro-inflammatory potential of the WSOM present in air particles, and whether an association can be discerned between the observed effects and the chemical characteristics of WSOM. The Estarreja region was selected as a case study because it has one of the largest chemical industrial complexes in Portugal, which alongside other industrial, urban, and agriculture activities, have been referred as exerting an important role on air quality in the region.
Type
Projet OHMs
OHM(s) concerné(s)
  • Estarreja
Disciplines
Biochimie, Chimie, Santé publique
Image

Porteur

Regina
Regina Maria Brandão De Oliveira Duarte
I am a Principal Researcher (FCT Investigator, IF/00798/2015) at the Department of Chemistry & Centre for Environmental and Marine Studies (CESAM), in the University of Aveiro. I have a degree in Analytical Chemistry (1998), a M.Sc. in Sciences of the Coastal Zone (2001), and a PhD in Chemistry (2006), all at the University of Aveiro. My scientific expertise is focused in Analytical and Environmental Chemistry, with emphasis on the analysis of complex environmental matrices, namely atmospheric aerosols. My current research interests include: 1| application of advanced multidimensional analytical techniques (e.g., NMR spectroscopy and two-dimensional liquid chromatography) for the characterization of natural organic matter, mainly from air particles; 2| atmospheric stressors; and 3| wet and dry deposition of organic aerosols. In the last 8 years, I have completed the supervision/co-supervision of 2 PhD students, 8 M.Sc. students, and 1 Post-doc fellow. I was the PI of 2 competitively funded FCT projects, and 1 Morocco-Portugal bilateral project, besides being Team Member in 1 European, 2 FCT, and 1 Brazil-Portugal bilateral projects. I also act as referee in international scientific journals (>45 papers in 14 journals) and as Evaluation Panel Member for NSF (USA), German Research Foundation, and COST. Since 2013, I am Management Committee Member from Portugal in COST Action CM1304-Emergence and Evolution of Complex Chemical Systems. I am an author/co-author of 40 articles in international peer-reviewed SCI journals (h index of 16), 7 book chapters, and more than 50 oral/poster communications in international and national scientific meetings.

Participants

Bruno
Neves
Bruno Neves is an invited assistant professor at FFUC and investigator at the Centre for Neuroscience and Cell Biology (CNC.IBILI), University of Coimbra. He has obtained a degree in Pharmaceutical Sciences (2006), and a PhD in Cellular and Molecular Biology (2011), all at the University of Coimbra.
He has an extensive expertise in cellular and molecular biology fields, namely in the molecular mechanisms behind dendritic cell maturation and in the establishment of cell-based tests for toxicological/pharmacological purposes. He has participated in the supervision/co-supervision of 2 PhD students, 10 M.Sc. students, and has participated as investigator or co-principal investigator in 10 projects with financial support from FCT, European Commission or international foundations. He is the author/co-author of 31 articles in international peer-reviewed SCI journals (h index of 13), and 4 book chapters. He has presented more than 40 oral/poster communications in international and national scientific meetings. Additional details in: https://orcid.org/0000-0001-7391-3124.
Carla
Patinha
Carla Patinha is technician at Department of Geoscience and researcher of GEOBIOTEC. She holds a PhD degree in Geosciences (2002), University of Aveiro. Since obtaining her PhD degree published 54 papers in international peer review journals. Carla Patinha has also published about 100 papers in International Conferences Proceedings. She has been participating and coordinating several national and international R&D Projects. Present research interests include research on oral and pulmonary bioaccessibility, solid-phase distribution of potentially harmful elements to human health, saline soils and their management and study geochemical records of environmental changes: climate changes and human activities. Additional details in: https://orcid.org/0000-0001-6006-344X.
Rita
Ferreira
Rita Ferreira is Assistant Professor in the Department of Chemistry at the University of Aveiro. She has obtained a degree in Biochemistry (1996) at the University of Porto, a M.Sc. in Chemistry of Natural Products and Foodstuffs (2000), and a PhD in Biochemistry (2006), at the University of Aveiro. She has expertise in Biochemistry applied to Health Sciences, with emphasis on the characterization of the molecular mechanisms underlying diseases. She has participated/participates in the supervision/co-supervision of 6 PhD students, 32 M.Sc. students, and 2 Post-doc fellows, and has participated and/or coordinated 13 projects with financial support from FCT and European Commission. She is the author/co-author of 134 articles in international peer-reviewed SCI journals (h index of 24), 1 national book and 5 book chapters. Additional details in: https://orcid.org/0000-0002-6872-4051.
Armando
Duarte
Armando Duarte is a Professor of Chemistry in the Department of Chemistry, at the University of Aveiro. He has a degree in Chemical Engineering (University of Porto, Portugal) and a PhD in Public Health Engineering (University of Newcastle-upon-Tyne, UK). He has expertise in Environmental Analytical Chemistry, and his current research interests include: 1| distribution, availability and fate of chemical compounds in different environmental compartments; 2| characterization of natural organic matter; and 3| Analytical Chemistry, Qualimetrics and Analytical Quality Assurance in relation to obtaining experimental data to support decisions on food safety, health and environmental protection, and sustainable development. He has participated in the supervision of 17 PhD students and 14 Post-doc fellows, and participated and/or coordinated more than 20 projects with financial support from FCT and European Commission. He is the author/co-author of 490 articles in international peer-reviewed SCI journals (h index of 43), more than 26 book chapters, and Editor of 5 books of international distribution. He has presented more than 280 oral/poster communications in international and national scientific meetings. Additional details in: http://orcid.org/0000-0002-4868-4099.